Precision in
Peptide Science
Advancing therapeutic discovery with a vertically integrated platform for peptide APIs. From early R&D to commercial scale.
Overview
- Utide operates an integrated 6,000 m² R&D center and a 14,000 m² production facility, staffed by over 200 professionals and equipped with advanced technologies for the synthesis, purification, and isolation of peptide APIs.
- The facility supports an annual production capacity of up to 1,500 kg while offering flexible custom peptide development capabilities, fully adhering to GMP standards.
6,000 m²
R&D Center
14,000 m²
Production
1,500 kg
Annual Capacity
200+
Professionals
Peptide Synthesis (Upstream Manufacturing)
We specialize in Solid-Phase Peptide Synthesis (SPPS), offering a vertically integrated manufacturing platform that scales seamlessly from early R&D to multi-kilogram commercial production.
1. SPPS Expertise
- By leveraging advanced Fmoc- and t-Boc-based solid-phase methodologies, our proven expertise allows for the precise synthesis of challenging peptide targets, including long-chain peptides, highly hydrophobic sequences, and complex multi-disulfide-bridged cyclic peptides.
- High-quality resins and optimised coupling reagents are employed to control impurity profiles from the earliest stages of synthesis.
2. Large-Scale Capacity
- Equipped with state-of-the-art SPPS reactors and dedicated cleavage units, we provide significant single-batch outputs to secure your large-scale supply.
- Beyond mere volume, our tiered reactor configurations—ranging from pilot to industrial scales—offer the flexibility to seamlessly support your project’s journey.
3. Advanced Automation
Fully automated synthesis systems provide real-time control over reagent charging, critical process parameters, and washing cycles, reducing manual variability and ensuring high crude purity with consistent batch-to-batch reproducibility.
Peptide Purification & Isolation (Downstream Processing)
Our downstream processing refines crude peptides generated via SPPS to exceptional purity levels through sophisticated purification and isolation technologies.
1. Industrial Prep-HPLC
Featuring high-pressure preparative HPLC systems, we effectively isolate and remove deletion sequences, truncated peptides, and diastereomers, consistently achieving purity levels of up to ≥99%, depending on peptide sequence characteristics.
2. Precise Salt Exchange
We offer flexible salt-form conversions (Acetate, HCl, Phosphate, or TFA) and meticulous de-salting processes, ensuring strict control over counter-ion distribution and residual solvents to meet diverse formulation requirements.
3. Large-Scale Lyophilization
In controlled cleanroom environments, high-capacity industrial freeze-dryers transform purified eluates into high-quality API powders with excellent solubility and physical characteristics.
